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Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

Ku or DNA ligase 4-independent alternative end joining (alt-EJ) repair of DNA double-strand breaks (DSBs) frequently correlates with increased junctional microhomology. However, alt-EJ also produces junctions without microhomology (apparent blunt joins), and the exact role of microhomology in both a...

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Autors principals: Yu, Amy Marie, McVey, Mitch
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943611/
https://ncbi.nlm.nih.gov/pubmed/20460465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq379
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