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Cation-dependent cleavage of the duplex form of the subtype-B HIV-1 RNA dimerization initiation site

The crystal structure of subtype-B HIV-1 genomic RNA Dimerization Initiation Site duplex revealed chain cleavage at a specific position resulting in 3′-phosphate and 5′-hydroxyl termini. A crystallographic analysis showed that Ba(2+), Mn(2+), Co(2+) and Zn(2+) bind specifically on a guanine base clo...

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Main Authors: Ennifar, Eric, Walter, Philippe, Dumas, Philippe
格式: Artigo
語言:Inglês
出版: Oxford University Press 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943608/
https://ncbi.nlm.nih.gov/pubmed/20460458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq344
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