Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell

The kissing-loop complex that initiates dimerization of genomic RNA is crucial for Human Immunodeficiency Virus Type 1 (HIV-1) replication. We showed that owing to its strong similitude with the bacterial ribosomal A site it can be targeted by aminoglycosides. Here, we present its crystal structure...

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Huvudupphovsmän: Ennifar, Eric, Paillart, Jean-Christophe, Bodlenner, Anne, Walter, Philippe, Weibel, Jean-Marc, Aubertin, Anne-Marie, Pale, Patrick, Dumas, Philippe, Marquet, Roland
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2006
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458285/
https://ncbi.nlm.nih.gov/pubmed/16679451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl317
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