Mutation of the ABCA1 C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation

HIV-1 infection and antiretroviral therapy associate with a dyslipidemia marked by low HDL levels and increased cardiovascular disease, but it is obscure whether virion replication plays a causative role in these changes. The HIV-1 Nef protein can impair ABCA1 cholesterol efflux from macrophages, a...

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Bibliographic Details
Main Authors: Mujawar, Zahedi, Tamehiro, Norimasa, Grant, Angela, Sviridov, Dmitri, Bukrinsky, Michael, Fitzgerald, Michael L.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943568/
https://ncbi.nlm.nih.gov/pubmed/20731376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100466q
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