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Oncogenic CARD11 Mutations Induce Hyperactive Signaling By Disrupting Autoinhibition by the PKC-Responsive Inhibitory Domain
The regulated activation of NF-κB by antigen receptor signaling is required for normal B and T lymphocyte activation during the adaptive immune response. Dysregulated NF-κB activation is associated with several types of lymphoma, including Diffuse Large B Cell Lymphoma (DLBCL). During normal antigen...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943563/ https://ncbi.nlm.nih.gov/pubmed/20799731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101052d |
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