Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

CARD9 and CARD11 drive immune cell activation by nucleating Bcl10 polymerization, but are held in an autoinhibited state prior to stimulation. Here, we elucidate the structural basis for this autoinhibition by determining the structure of a region of CARD9 that includes an extensive interface betwee...

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Publicat a:Nat Commun
Autors principals: Holliday, Michael J., Witt, Axel, Rodríguez Gama, Alejandro, Walters, Benjamin T., Arthur, Christopher P., Halfmann, Randal, Rohou, Alexis, Dueber, Erin C., Fairbrother, Wayne J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624267/
https://ncbi.nlm.nih.gov/pubmed/31296852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10953-z
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