Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

CARD9 and CARD11 drive immune cell activation by nucleating Bcl10 polymerization, but are held in an autoinhibited state prior to stimulation. Here, we elucidate the structural basis for this autoinhibition by determining the structure of a region of CARD9 that includes an extensive interface betwee...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Holliday, Michael J., Witt, Axel, Rodríguez Gama, Alejandro, Walters, Benjamin T., Arthur, Christopher P., Halfmann, Randal, Rohou, Alexis, Dueber, Erin C., Fairbrother, Wayne J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624267/
https://ncbi.nlm.nih.gov/pubmed/31296852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10953-z
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker