Genomic and biological characterization of exon 4 KRAS mutations in human cancer

Mutations in RAS proteins occur widely in human cancer. Prompted by confirmation of KRAS mutation as a predictive biomarker of response to EGFR targeted therapies, limited clinical testing for RAS pathway mutations has recently been adopted. We performed a multiplatform genomic analysis to character...

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Autori principali: Janakiraman, Manickam, Vakiani, Efsevia, Zeng, Zhaoshi, Pratilas, Christine A., Taylor, Barry S., Chitale, Dhananjay, Halilovic, Ensar, Wilson, Manda, Huberman, Kety, Filho, Julio Cezar Ricarte, Persaud, Yogindra, Levine, Douglas A., Fagin, James A., Jhanwar, Suresh C., Mariadason, John M., Lash, Alex, Ladanyi, Marc, Saltz, Leonard B., Heguy, Adriana, Paty, Philip B., Solit, David B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943514/
https://ncbi.nlm.nih.gov/pubmed/20570890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0192
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