Genetic predictors of MEK-dependence in non-small cell lung cancer

Hyperactivated ERK signaling is common in human cancer and is often the result of activating mutations in BRAF, RAS and upstream receptor tyrosine kinases. In order to characterize the MEK/ERK dependence of lung cancers harboring BRAF kinase domain mutations, we screened a large panel of human lung...

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Main Authors: Pratilas, Christine A., Hanrahan, Aphrothiti J., Halilovic, Ensar, Persaud, Yogindra, Soh, Junichi, Chitale, Dhananjay, Shigematsu, Hisayuki, Yamamoto, Hiromasa, Sawai, Ayana, Janakiraman, Manickam, Taylor, Barry S., Pao, William, Toyooka, Shinichi, Ladanyi, Marc, Gazdar, Adi, Rosen, Neal, Solit, David B.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649746/
https://ncbi.nlm.nih.gov/pubmed/19010912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2223
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