NPM1 Deletion Is Associated with Gross Chromosomal Rearrangements in Leukemia

BACKGROUND: NPM1 gene at chromosome 5q35 is involved in recurrent translocations in leukemia and lymphoma. It also undergoes mutations in 60% of adult acute myeloid leukemia (AML) cases with normal karyotype. The incidence and significance of NPM1 deletion in human leukemia have not been elucidated....

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Autors principals: La Starza, Roberta, Matteucci, Caterina, Gorello, Paolo, Brandimarte, Lucia, Pierini, Valentina, Crescenzi, Barbara, Nofrini, Valeria, Rosati, Roberto, Gottardi, Enrico, Saglio, Giuseppe, Santucci, Antonella, Berchicci, Laura, Arcioni, Francesco, Falini, Brunangelo, Martelli, Massimo Fabrizio, Sambani, Constantina, Aventin, Anna, Mecucci, Cristina
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943467/
https://ncbi.nlm.nih.gov/pubmed/20877721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012855
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