Denaturing High-Performance Liquid Chromatography : A Valid Approach for Identifying NPM1 Mutations in Acute Myeloid Leukemia

NPM1 gene mutations are the most frequent genetic lesion in the 60% of adult acute myeloid leukemias (AMLs) with normal karyotype and no evidence of typical fusion genes (BCR/ABL1, PML/RARA, AML1/ETO, CBFB/MYH11, DEK/CAN). Using direct sequencing we previously identified six different heterozygous m...

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Detalhes bibliográficos
Main Authors: Roti, Giovanni, Rosati, Roberto, Bonasso, Rossella, Gorello, Paolo, Diverio, Daniela, Martelli, Massimo Fabrizio, Falini, Brunangelo, Mecucci, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867590/
https://ncbi.nlm.nih.gov/pubmed/16645213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2006.050098
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