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Regulation of Opioid Tolerance by let-7 Family MicroRNA Targeting the μ Opioid Receptor

MicroRNA has emerged as a critical regulator of neuronal functions. This study aimed to test whether let-7 microRNAs can regulate the μ opioid receptor (MOR) and opioid tolerance. Employing bioinformatics, we identified a let-7 binding site in the 3′-untranslated region (UTR) of MOR mRNA, which was...

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Autori principali: He, Ying, Yang, Cheng, Kirkmire, Chelsea M., Wang, Zaijie Jim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943348/
https://ncbi.nlm.nih.gov/pubmed/20668208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2419-10.2010
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