Metabolic Regulator βKlotho Interacts with Fibroblast Growth Factor Receptor 4 (FGFR4) to Induce Apoptosis and Inhibit Tumor Cell Proliferation

In organs involved in metabolic homeostasis, transmembrane α and βklothos direct FGFR signaling to control of metabolic pathways. Coordinate expression of βklotho and FGFR4 is a property of mature hepatocytes. Genetic deletion of FGFR4 or βklotho in mice disrupts hepatic cholesterol/bile acid and li...

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Bibliographische Detailangaben
Hauptverfasser: Luo, Yongde, Yang, Chaofeng, Lu, Weiqin, Xie, Rui, Jin, Chengliu, Huang, Peng, Wang, Fen, McKeehan, Wallace L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943257/
https://ncbi.nlm.nih.gov/pubmed/20657013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.148288
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