An iron-export ferroxidase activity of β-amyloid protein precursor is inhibited by zinc in Alzheimer’s Disease

Alzheimer’s Disease (AD) is complicated by pro-oxidant intraneuronal Fe(2+) elevation as well as extracellular Zn(2+) accumulation within amyloid plaque. We found that the AD β-amyloid protein precursor (APP) possesses ferroxidase activity mediated by a conserved H-ferritin-like active site, which i...

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Detalhes bibliográficos
Main Authors: Duce, James A., Tsatsanis, Andrew, Cater, Michael A., James, Simon A., Robb, Elysia, Wikhe, Krutika, Leong, Su Ling, Perez, Keyla, Johanssen, Timothy, Greenough, Mark A., Cho, Hyun-Hee, Galatis, Denise, Moir, Robert D., Masters, Colin L., McLean, Catriona, Tanzi, Rudolph E., Cappai, Roberto, Barnham, Kevin J., Ciccotosto, Giuseppe D., Rogers, Jack T., Bush, Ashley I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943017/
https://ncbi.nlm.nih.gov/pubmed/20817278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.08.014
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