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Conformational flexibility of transmembrane helix VII of the human serotonin transporter impacts ion dependence and transport
The serotonin transporter (SERT) regulates the serotonin concentration in the synapse and is a target of several antidepressant and psychostimulant drugs. Previous work suggested that the middle transmembrane helices (TMHs) of the biogenic amine transporters (TMHs) play a role in substrate and ion r...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2942994/ https://ncbi.nlm.nih.gov/pubmed/20637736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.07.005 |
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