Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(−9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs775...

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Detalhes bibliográficos
Main Authors: Perry, John R B, Stolk, Lisette, Franceschini, Nora, Lunetta, Kathryn L, Zhai, Guangju, McArdle, Patrick F, Smith, Albert V, Aspelund, Thor, Bandinelli, Stefania, Boerwinkle, Eric, Cherkas, Lynn, Eiriksdottir, Gudny, Estrada, Karol, Ferrucci, Luigi, Folsom, Aaron R, Garcia, Melissa, Gudnason, Vilmundur, Hofman, Albert, Karasik, David, Kiel, Douglas P, Launer, Lenore J, van Meurs, Joyce, Nalls, Michael A, Rivadeneira, Fernando, Shuldiner, Alan R, Singleton, Andrew, Soranzo, Nicole, Tanaka, Toshiko, Visser, Jenny A, Weedon, Michael N, Wilson, Scott G, Zhuang, Vivian, Streeten, Elizabeth A, Harris, Tamara B, Murray, Anna, Spector, Tim D, Demerath, Ellen W, Uitterlinden, André G, Murabito, Joanne M
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2942986/
https://ncbi.nlm.nih.gov/pubmed/19448620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.386
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