Double Duty for a Conserved Glutamate in Pyruvate Decarboxylase: Evidence of the Participation in Stereoelectronically Controlled Decarboxylation and in Protonation of the Nascent Carbanion/Enamine Intermediate,

Pyruvate decarboxylase (PDC) catalyzes the nonoxidative decarboxylation of pyruvate into acetaldehyde and carbon dioxide and requires thiamin diphosphate (ThDP) and a divalent cation as cofactors. Recent studies have permitted the assignment of functional roles of active site residues; however, the...

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Hlavní autoři: Meyer, Danilo, Neumann, Piotr, Parthier, Christoph, Friedemann, Rudolf, Nemeria, Natalia, Jordan, Frank, Tittmann, Kai
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2942768/
https://ncbi.nlm.nih.gov/pubmed/20715795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100828r
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