Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function.

In phagocytes, superoxide generation by the NADPH oxidase is accompanied by metabolic acid production. Cytoplasmic acidification during this metabolic burst is prevented by a combination of H+ extrusion mechanisms, including a unique H+ conductance. NADPH oxidase is deficient in chronic granulomatou...

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Pubblicato in:	J Clin Invest
Autori principali:	Nanda, A, Curnutte, J T, Grinstein, S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8163676/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117162
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