Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function.
In phagocytes, superoxide generation by the NADPH oxidase is accompanied by metabolic acid production. Cytoplasmic acidification during this metabolic burst is prevented by a combination of H+ extrusion mechanisms, including a unique H+ conductance. NADPH oxidase is deficient in chronic granulomatou...
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| Опубликовано в:: | J Clin Invest |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
1994
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8163676/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117162 |
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