Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.

A new immunoassay was developed to detect denaturation of type II collagen in osteoarthritis (OA). A peptide, alpha 1 (II)-CB11B, located in the CB11 peptide of type II collagen, was synthesized and used to produce a monoclonal antibody (COL2-3/4m) of the IgG1 (kappa) isotype. This reacts with a def...

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Publicat a:J Clin Invest
Autors principals: Hollander, A P, Heathfield, T F, Webber, C, Iwata, Y, Bourne, R, Rorabeck, C, Poole, A R
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294227/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7512992/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117156
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