Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice.

We have generated transgenic mice expressing the human apolipoprotein CII (apoCII) gene under the transcriptional control of the human cytochrome P-450 IA1 (CYPIA1) promoter. Human apoCII transgenic (HuCIITg) mice exhibited significant basal expression of the transgene (plasma apoCII level = 26.1 +/...

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Bibliographic Details

Published in:	J Clin Invest
Main Authors:	Shachter, N S, Hayek, T, Leff, T, Smith, J D, Rosenberg, D W, Walsh, A, Ramakrishnan, R, Goldberg, I J, Ginsberg, H N, Breslow, J L
Format:	Artigo
Language:	Inglês
Published:	American Society for Clinical Investigation 1994
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294216/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8163669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117151
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