The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation

The multi-functional adaptor protein NEDD9/HEF1/Cas-L regulates cell motility, invasion and cell cycle progression, and plays key roles in cancer progression and metastasis. NEDD9 is localized to the centrosome and is required for activation of Aurora A kinase in mitosis. Here we demonstrate that th...

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Autores principales: Moore, Finola E, Osmundson, Evan C, Koblinski, Jennifer, Pugacheva, Elena, Golemis, Erica A, Ray, Dipankar, Kiyokawa, Hiroaki
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941750/
https://ncbi.nlm.nih.gov/pubmed/20825672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-5-22
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