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The potent bactericidal activity of streptomycin in the guinea pig model of tuberculosis ceases due to the presence of persisters
OBJECTIVES: The biphasic kill curve of isoniazid against Mycobacterium tuberculosis in guinea pigs is due to the presence of persisters rather than selection of isoniazid-resistant mutants. To determine whether this phenomenon is common to other bactericidal drugs, we studied the activity of strepto...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2941674/ https://ncbi.nlm.nih.gov/pubmed/20693172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkq277 |
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