Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

Tat activating regulatory DNA-binding protein (Tardbp or TDP-43), a highly conserved metazoan DNA/RNA binding protein thought to be involved in RNA transcription and splicing, has been linked to the pathophysiology of amyotrophic lateral sclerosis and frontotemporal lobar degeneration and is essenti...

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Bibliographic Details
Main Authors: Chiang, Po-Min, Ling, Jonathan, Jeong, Yun Ha, Price, Donald L., Aja, Susan M., Wong, Philip C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941284/
https://ncbi.nlm.nih.gov/pubmed/20660762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002176107
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