Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients

BACKGROUND: Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (DPYD). METHODS: In this study, we evaluated DPYD promoter methylation through quantitative methy...

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Hauptverfasser: Savva-Bordalo, Joana, Ramalho-Carvalho, João, Pinheiro, Manuela, Costa, Vera L, Rodrigues, Ângelo, Dias, Paula C, Veiga, Isabel, Machado, Manuela, Teixeira, Manuel R, Henrique, Rui, Jerónimo, Carmen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940808/
https://ncbi.nlm.nih.gov/pubmed/20809970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-470
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