Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy

BACKGROUND: The activity of dihydropyrimidine dehydrogenase (DPD), the key enzyme of pyrimidine catabolism, is thought to be an important determinant for the occurrence of severe toxic reactions to 5-fluorouracil (5-FU), which is one of the most commonly prescribed chemotherapeutic agents for the tr...

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Detalhes bibliográficos
Main Authors: Amstutz, Ursula, Farese, Simone, Aebi, Stefan, Largiadèr, Carlo R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584619/
https://ncbi.nlm.nih.gov/pubmed/18937829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-27-54
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