Absence of large intragenic rearrangements in the DPYD gene in a large cohort of colorectal cancer patients treated with 5-FU-based chemotherapy

AIMS: To study the relationship between the toxicity associated with a 5-FU-based therapy and the presence of (i) the large intragenic rearrangements in the DPYD gene and (ii) the IVS14+1G>A mutation. METHODS: We used the multiplex ligation-dependent probe amplification technique (MLPA) to study...

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Detalhes bibliográficos
Main Authors: Paré, Laia, Paez, David, Salazar, Juliana, del Rio, Elisabeth, Tizzano, Eduardo, Marcuello, Eugenio, Baiget, Montserrat
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911557/
https://ncbi.nlm.nih.gov/pubmed/20653680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03683.x
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