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Correlated Mutations: A Hallmark of Phenotypic Amino Acid Substitutions

Point mutations resulting in the substitution of a single amino acid can cause severe functional consequences, but can also be completely harmless. Understanding what determines the phenotypical impact is important both for planning targeted mutation experiments in the laboratory and for analyzing n...

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Detalhes bibliográficos
Main Authors: Kowarsch, Andreas, Fuchs, Angelika, Frishman, Dmitrij, Pagel, Philipp
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940720/
https://ncbi.nlm.nih.gov/pubmed/20862353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000923
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