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mTOR signaling in glioblastoma: lessons learned from bench to bedside

Phosphatidyl-inositol-3 kinases (PI3Ks) constitute a family of intracellular lipid kinases that are frequently hyperactivated in glioblastoma. The PI3K complex links growth factor signaling with cellular proliferation, differentiation, metabolism, and survival. Mammalian target of rapamycin (mTOR) a...

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Bibliografiske detaljer
Main Authors: Akhavan, David, Cloughesy, Timothy F., Mischel, Paul S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940679/
https://ncbi.nlm.nih.gov/pubmed/20472883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq052
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