Intracerebral administration of CpG oligonucleotide for patients with recurrent glioblastoma: a phase II study

Immunostimulating oligodeoxynucleotides containing CpG motifs (CpG-ODN) have shown promising efficacy in cancer models when injected locally. In a phase I clinical trial, intratumoral infusions of CpG-ODN in glioblastoma (GBM) patients were well tolerated at doses up to 20 mg. This phase II trial wa...

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Detalhes bibliográficos
Main Authors: Carpentier, Alexandre, Metellus, Philippe, Ursu, Renata, Zohar, Sarah, Lafitte, Francois, Barrié, Maryline, Meng, Yuxia, Richard, Margaretha, Parizot, Christophe, Laigle-Donadey, Florence, Gorochov, Guy, Psimaras, Dimitri, Sanson, Marc, Tibi, Annick, Chinot, Olivier, Carpentier, Antoine F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940609/
https://ncbi.nlm.nih.gov/pubmed/20308317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop047
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