Akt2 and Akt3 play a pivotal role in malignant gliomas

Akt, one of the major downstream effectors of phosphatidylinositol 3-kinase, is hyper-expressed and activated in a variety of cancers including glioblastoma. However, the expression profiles of the Akt isoforms Akt1/PKBα, Akt2/PKBβ, and Akt3/PKBγ and their functional roles in malignant glioma are no...

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Autori principali: Mure, Hideo, Matsuzaki, Kazuhito, Kitazato, Keiko T., Mizobuchi, Yoshifumi, Kuwayama, Kazuyuki, Kageji, Teruyoshi, Nagahiro, Shinji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940586/
https://ncbi.nlm.nih.gov/pubmed/20167810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop026
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