Phospholipase C Signaling via the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Is Essential for Normal Bone Responses to PTH

We have previously shown that differentiation of hypertrophic chondrocytes is delayed in mice expressing a mutated PTH/PTHrP receptor (PTHR) (called DSEL here) that stimulates adenylyl cyclase normally but fails to activate phospholipase C (PLC). To better understand the role of PLC signaling via th...

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Main Authors: Guo, Jun, Liu, Minlin, Yang, Dehong, Bouxsein, Mary L., Thomas, Clare C., Schipani, Ernestina, Bringhurst, F. Richard, Kronenberg, Henry M.
Formato: Artigo
Idioma:Inglês
Publicado: The Endocrine Society 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940537/
https://ncbi.nlm.nih.gov/pubmed/20501677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1494
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