Absence of Thyroid Hormone Activation during Development Underlies a Permanent Defect in Adaptive Thermogenesis

Type 2 deiodinase (D2), which is highly expressed in brown adipose tissue (BAT), is an enzyme that amplifies thyroid hormone signaling in individual cells. Mice with inactivation of the D2 pathway (D2KO) exhibit dramatically impaired thermogenesis in BAT, leading to hypothermia during cold exposure...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Hall, Jessica A., Ribich, Scott, Christoffolete, Marcelo A., Simovic, Gordana, Correa-Medina, Mayrin, Patti, Mary Elizabeth, Bianco, Antonio C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Endocrine Society 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940501/
https://ncbi.nlm.nih.gov/pubmed/20660060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0511
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller