The Thyroid Hormone-Inactivating Type III Deiodinase Is Expressed in Mouse and Human β-Cells and Its Targeted Inactivation Impairs Insulin Secretion

Deiodinases are selenoproteins that activate or inactivate thyroid hormone. During vertebrate development, these pathways control thyroid hormone action in a cell-specific fashion explaining how systemic thyroid hormone can affect local control of tissue embryogenesis. Here we investigated the role...

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Autori principali: Medina, Mayrin C., Molina, Judith, Gadea, Yelena, Fachado, Alberto, Murillo, Monika, Simovic, Gordana, Pileggi, Antonello, Hernández, Arturo, Edlund, Helena, Bianco, Antonio C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2011
Soggetti:
General Endocrinology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176649/
https://ncbi.nlm.nih.gov/pubmed/21828183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1210
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