Absence of Thyroid Hormone Activation during Development Underlies a Permanent Defect in Adaptive Thermogenesis

Type 2 deiodinase (D2), which is highly expressed in brown adipose tissue (BAT), is an enzyme that amplifies thyroid hormone signaling in individual cells. Mice with inactivation of the D2 pathway (D2KO) exhibit dramatically impaired thermogenesis in BAT, leading to hypothermia during cold exposure...

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Detalhes bibliográficos
Main Authors: Hall, Jessica A., Ribich, Scott, Christoffolete, Marcelo A., Simovic, Gordana, Correa-Medina, Mayrin, Patti, Mary Elizabeth, Bianco, Antonio C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940501/
https://ncbi.nlm.nih.gov/pubmed/20660060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0511
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