Absence of Thyroid Hormone Activation during Development Underlies a Permanent Defect in Adaptive Thermogenesis

Type 2 deiodinase (D2), which is highly expressed in brown adipose tissue (BAT), is an enzyme that amplifies thyroid hormone signaling in individual cells. Mice with inactivation of the D2 pathway (D2KO) exhibit dramatically impaired thermogenesis in BAT, leading to hypothermia during cold exposure...

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Bibliografiset tiedot
Päätekijät: Hall, Jessica A., Ribich, Scott, Christoffolete, Marcelo A., Simovic, Gordana, Correa-Medina, Mayrin, Patti, Mary Elizabeth, Bianco, Antonio C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Endocrine Society 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940501/
https://ncbi.nlm.nih.gov/pubmed/20660060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0511
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