Absence of Thyroid Hormone Activation during Development Underlies a Permanent Defect in Adaptive Thermogenesis

Type 2 deiodinase (D2), which is highly expressed in brown adipose tissue (BAT), is an enzyme that amplifies thyroid hormone signaling in individual cells. Mice with inactivation of the D2 pathway (D2KO) exhibit dramatically impaired thermogenesis in BAT, leading to hypothermia during cold exposure...

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Bibliografische gegevens
Hoofdauteurs: Hall, Jessica A., Ribich, Scott, Christoffolete, Marcelo A., Simovic, Gordana, Correa-Medina, Mayrin, Patti, Mary Elizabeth, Bianco, Antonio C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Endocrine Society 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940501/
https://ncbi.nlm.nih.gov/pubmed/20660060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0511
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