Central Injection of the Stable Somatostatin Analog ODT8-SST Induces a Somatostatin(2) Receptor-Mediated Orexigenic Effect: Role of Neuropeptide Y and Opioid Signaling Pathways in Rats

Somatostatin and octreotide injected into the brain have been reported to modulate food intake. However, little is known regarding the underlying mechanisms. The stable oligosomatostatin analog, des-AA(1,2,4,5,12,13)-[DTrp(8)]-somatostatin (ODT8-SST), like somatostatin, binds to all five somatostati...

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Detalhes bibliográficos
Main Authors: Stengel, Andreas, Coskun, Tamer, Goebel, Miriam, Wang, Lixin, Craft, Libbey, Alsina-Fernandez, Jorge, Rivier, Jean, Taché, Yvette
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940496/
https://ncbi.nlm.nih.gov/pubmed/20610566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0195
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