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Evaluation of retinoic acid therapy for OTX2-positive medulloblastomas

The homeobox transcription factor OTX2 plays an essential role during embryonic brain development. It is normally silenced in the adult brain, but is overexpressed by genomic amplification or other mechanisms in the majority of medulloblastomas (MBs). Retinoic acids (RAs) can suppress OTX2 expressio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bai, Renyuan, Siu, I-Mei, Tyler, Betty M., Staedtke, Verena, Gallia, Gary L., Riggins, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940451/
https://ncbi.nlm.nih.gov/pubmed/20511190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop062
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