A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene.

We describe the spontaneous progression of a colon adenoma cell line to tumorigenicity and growth factor independence. This system allows direct comparison of biologic stages of malignant progression with alterations of colon cancer suppressor genes and oncogenes. VACO-235, a human colon adenoma cel...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Markowitz, S D, Myeroff, L, Cooper, M J, Traicoff, J, Kochera, M, Lutterbaugh, J, Swiriduk, M, Willson, J K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294021/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8132740/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117048
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