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Defective Ribosomal Products Are the Major Source of Antigenic Peptides Endogenously Generated from Influenza A Virus Neuraminidase

The defective ribosomal product (DRiP) hypothesis of endogenous Ag processing posits that rapidly degraded forms of nascent proteins are a major source of peptide ligands for MHC class I molecules. Although there is broad experimental support for the DRiP hypothesis, careful kinetic analysis of the...

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Autors principals: Dolan, Brian P., Li, Lily, Takeda, Kazuyo, Bennink, Jack R., Yewdell, Jonathan W.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940057/
https://ncbi.nlm.nih.gov/pubmed/20038640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901907
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