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Distinct Pathways Generate Peptides from Defective Ribosomal Products for CD8(+) T Cell Immunosurveillance
To understand better the endogenous sources of MHC class I peptide ligands, we generated an antigenic reporter protein whose degradation is rapidly and reversibly controlled with Shield-1, a cell-permeant drug. Using this system, we demonstrate that defective ribosomal products (DRiPs) represent a m...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408966/ https://ncbi.nlm.nih.gov/pubmed/21228349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003096 |
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