Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters

Sensitivity is essential in CD8+ T-cell killing of virus-infected cells and tumor cells. Although the affinity of the T-cell receptor (TCR) for antigen is relatively low, the avidity of T cell-antigen–presenting cell interactions is greatly enhanced by increasing the valence of the interaction. It i...

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Autores principales: Lu, Xiuju, Gibbs, James S., Hickman, Heather D., David, Alexandre, Dolan, Brian P., Jin, Yetao, Kranz, David M., Bennink, Jack R., Yewdell, Jonathan W., Varma, Rajat
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458372/
https://ncbi.nlm.nih.gov/pubmed/22949678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208696109
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