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MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA

To better understand the generation of MHC class I-associated peptides, we used a model antigenic protein whose proteasome-mediated degradation is rapidly and reversibly controlled by Shield-1, a cell-permeant drug. When expressed from a stably transfected gene, the efficiency of antigen presentatio...

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Bibliografiske detaljer
Main Authors: Dolan, Brian P., Sharma, Aditi A., Gibbs, James S., Cunningham, Tshaka J., Bennink, Jack R., Yewdell, Jonathan W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344963/
https://ncbi.nlm.nih.gov/pubmed/22509014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112387109
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