Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition

BACKGROUND: Akt is a critical mediator of developmental skeletal muscle growth. Treatment with a soluble ActRIIB fusion protein (ActRIIB-mFc) increases skeletal muscle mass and strength by inhibiting myostatin and related peptides. Recent in vitro studies have suggested that Akt signaling is necessa...

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Detalhes bibliográficos
Main Authors: Goncalves, Marcus D., Pistilli, Emidio E., Balduzzi, Anthony, Birnbaum, Morris J., Lachey, Jennifer, Khurana, Tejvir S., Ahima, Rexford S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939888/
https://ncbi.nlm.nih.gov/pubmed/20856813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012707
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