Neutralisation of uPA with a Monoclonal Antibody Reduces Plasmin Formation and Delays Skin Wound Healing in tPA-Deficient Mice

BACKGROUND: Proteolytic degradation by plasmin and metalloproteinases is essential for epidermal regeneration in skin wound healing. Plasminogen deficient mice have severely delayed wound closure as have mice simultaneously lacking the two plasminogen activators, urokinase-type plasminogen activator...

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Autors principals: Jögi, Annika, Rønø, Birgitte, Lund, Ida K., Nielsen, Boye S., Ploug, Michael, Høyer-Hansen, Gunilla, Rømer, John, Lund, Leif R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939870/
https://ncbi.nlm.nih.gov/pubmed/20856796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012746
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