Neutralisation of uPA with a Monoclonal Antibody Reduces Plasmin Formation and Delays Skin Wound Healing in tPA-Deficient Mice

BACKGROUND: Proteolytic degradation by plasmin and metalloproteinases is essential for epidermal regeneration in skin wound healing. Plasminogen deficient mice have severely delayed wound closure as have mice simultaneously lacking the two plasminogen activators, urokinase-type plasminogen activator...

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Detalhes bibliográficos
Main Authors: Jögi, Annika, Rønø, Birgitte, Lund, Ida K., Nielsen, Boye S., Ploug, Michael, Høyer-Hansen, Gunilla, Rømer, John, Lund, Leif R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939870/
https://ncbi.nlm.nih.gov/pubmed/20856796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012746
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