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JNK1 participates in the VHL-independent HIF-1α degradation pathway by regulating Hsp90/Hsp70 turnover and the HDAC6-dependent chaperone activity
Hypoxia induced factor-1α (HIF-1α) is a master transcription factor that is critical for the regulation of various cellular functions. HIF-1α is rapidly degraded via a von Hippel-Lindau tumor suppressor gene product (VHL)-mediated ubiquitin-proteasome pathway in normoxia conditions. Most recent stud...
Kaydedildi:
| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939838/ https://ncbi.nlm.nih.gov/pubmed/20068160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0448 |
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