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mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging

Epidermal integrity is a complex process established during embryogenesis and maintained throughout the organism lifespan by epithelial stem cells. While Wnt regulates normal epithelial stem cell renewal, aberrant Wnt signaling can contribute to cancerous growth. Here, we explored the consequences o...

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Hlavní autoři: Castilho, R. M., Squarize, C. H., Chodosh, L. A., Williams, B. O., Gutkind, J. Silvio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939833/
https://ncbi.nlm.nih.gov/pubmed/19733540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.06.017
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