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mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging

Epidermal integrity is a complex process established during embryogenesis and maintained throughout the organism lifespan by epithelial stem cells. While Wnt regulates normal epithelial stem cell renewal, aberrant Wnt signaling can contribute to cancerous growth. Here, we explored the consequences o...

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Detalles Bibliográficos
Main Authors: Castilho, R. M., Squarize, C. H., Chodosh, L. A., Williams, B. O., Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939833/
https://ncbi.nlm.nih.gov/pubmed/19733540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.06.017
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