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mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging

Epidermal integrity is a complex process established during embryogenesis and maintained throughout the organism lifespan by epithelial stem cells. While Wnt regulates normal epithelial stem cell renewal, aberrant Wnt signaling can contribute to cancerous growth. Here, we explored the consequences o...

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Main Authors: Castilho, R. M., Squarize, C. H., Chodosh, L. A., Williams, B. O., Gutkind, J. Silvio
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939833/
https://ncbi.nlm.nih.gov/pubmed/19733540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.06.017
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