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Comparative Effects of the Endogenous Agonist Glucagon-Like Peptide-1 (GLP-1)-(7-36) Amide and the Small-Molecule Ago-Allosteric Agent “Compound 2” at the GLP-1 Receptor

Glucagon-like peptide-1 (GLP-1) mediates antidiabetogenic effects through the GLP-1 receptor (GLP-1R), which is targeted for the treatment of type 2 diabetes. Small-molecule GLP-1R agonists have been sought due to difficulties with peptide therapeutics. Recently, 6,7-dichloro-2-methylsulfonyl-3-N-te...

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Bibliografiske detaljer
Main Authors: Coopman, Karen, Huang, Yan, Johnston, Neil, Bradley, Sophie J., Wilkinson, Graeme F., Willars, Gary B.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939672/
https://ncbi.nlm.nih.gov/pubmed/20507928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.166009
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